Kochman J, et al. “Health Benefits and Chemical Composition of Matcha Green Tea: A Review.” Molecules. 2021;26(1):85. PMC7796401
Weiss DJ, Anderton CR. “Determination of catechins in matcha green tea by micellar electrokinetic chromatography.” Journal of Chromatography A. 2003;1011(1-2):173-180.(EGCG濃度が中国産緑茶の137倍であることを示した研究)
老化の抑制・抗酸化:
Anas Sohail A, et al. 2025年メタ分析(38のRCT):緑茶カテキンが抗酸化能力を高め、脂質過酸化マーカー(MDA)を有意に低下させることを確認。参照元: Matcha: The Science Beyond the Trend, MedReport Foundation, 2026.
Anas Sohail A, et al. “Green tea extract supplementation and oxidative stress: A meta-analysis of randomized controlled trials.” 2024年メタ分析(10のRCT):MDA値の有意な低下を確認(WMD=-0.32 µmol/l)。参照元: EGCG Cognitive Vitality Report, Alzheimer’s Drug Discovery Foundation, 2025.
脳の認知機能保護:
Baba Y, et al. “Effect of matcha green tea on cognitive functions and sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months.” PLOS ONE. 2024. DOI:10.1371/journal.pone.0309287(99名の高齢者対象、12ヶ月間のRCT。1日2gの抹茶で社会的認知機能の有意な改善を確認)
Rezai-Zadeh K, et al. “Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice.” Brain Research. 2008;1214:177-187.(EGCGが血液脳関門を通過しアミロイドβ蓄積を抑制)
がん予防の可能性:
Capasso L, et al. “Epigallocatechin gallate (EGCG): Pharmacological properties, biological activities and therapeutic potential.” Molecules. 2025;30:654.
Capasso L, et al. “Influence of Matcha and Tea Catechins on the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).” Nutrients. 2025;17(15):2532. DOI:10.3390/nu17152532(ヒト試験・動物試験の双方で体重・コレステロール・肝機能への好影響を確認)
免疫機能の強化:
メタ分析(3,748名対象):緑茶カテキンが上気道感染症のリスクを有意に低下(RR=0.74)、インフルエンザのリスク低下(RR=0.69)。参照元: EGCG Cognitive Vitality Report, Alzheimer’s Drug Discovery Foundation, 2025.
Juneja LR, et al. “L-theanine — a unique amino acid of green tea and its relaxation effect in humans.” Trends in Food Science & Technology. 1999;10(6-7):199-204.(テアニン摂取後にα波が増加することを確認した初期の重要研究)
認知機能・注意力への相乗効果:
Kelly SP, et al. “L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance.” Journal of Nutrition. 2008;138(8):1572S-1577S.(テアニンとカフェインの併用が注意力課題のパフォーマンスを向上させることを確認)
Anas Sohail A, et al. “The Cognitive-Enhancing Outcomes of Caffeine and L-theanine: A Systematic Review.” Cureus. 2021;13(12):e20828. DOI:10.7759/cureus.20828(カフェインとテアニンの認知機能増強効果に関する系統的レビュー)
ストレス軽減・不安抑制:
Unno K, et al. “Anti-stress effects of drinking green tea with lowered caffeine and enriched theanine, epigallocatechin and arginine on psychosocial stress induced adrenal hypertrophy in mice.” Phytomedicine. 2016;23:1365-1374.(テアニンとアルギニンを豊富に含む抹茶のストレス軽減効果を動物実験で確認)
Dietz C, Dekker M. “Effect of Green Tea Phytochemicals on Mood and Cognition.” Current Pharmaceutical Design. 2017;23(19):2876-2905.(テアニン・EGCG・カフェインが気分と認知に与える影響の包括的レビュー。抹茶の現実的な摂取量で注意力と記憶力への効果を確認)
睡眠の質:
Baba Y, et al. PLOS ONE. 2024.(前掲の12ヶ月間RCT。抹茶群で睡眠の質の改善傾向も確認(p=0.088))
メタ分析:
Payne ER, et al. “The effects of tea or its bioactive compounds L-theanine or L-theanine plus caffeine on cognition, sleep, and mood: a systematic review and meta-analysis of randomised controlled trials.” Proceedings of the Nutrition Society. 2024;83(OCE4). DOI:10.1017/S0029665124005202
Mátyus RO, et al. “Promising, but Not Completely Conclusive — The Effect of L-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.” Journal of Clinical Medicine. 2025;14(21):7710. DOI:10.3390/jcm14217710
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